The Valtiberina region takes its name from the Tiber River, which winds its way through Tuscany from Emilia-Romagna and onward into Umbria and Lazio. Think of it simply as the upper Tiber valley: it’s long been associated with the travels of Saint Francis and the artwork of area native son Piero della Francesca, who frequently used his homeland as the artistic basis for his landscapes. Early Renaissance enthusiasts and those curious about religious history will of course be at home here, but the region holds more than a few surprises, too.